http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-482415-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_38214d2b61566e8b243556d174e623c6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-08 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-08 |
| filingDate | 1979-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1980-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-482415-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF THE SALT OF 4-AMINOHEX-5-INOICO OR A SALT OF THE SAME. |
| abstract | Procedure for the preparation of the 4-aminohex-5-ionic salt or a salt thereof, characterized in that it consists in treating a pyrrolidone compound of the formula **(Formula)** where R1 is hydroxy, amino or tertiary butoxy , with a strong base in a lower alcohol solvent at a temperature of about 20°C. At the reflux temperature of the solvent for about 6 to 23 hours when R1 is amino, decarboxylate the 3-carboxy derivative or its tertiary butyl ester to provide the 5-vinyl-2-pyrrolidone which is treated in a chlorinated hydrocarbon solvent or acetic acid with an equivalent amount of bromine at a temperature of about 0° to 35°C. With stirring for about 4 to 24 hours, treat the thus formed dibromo intermediate in a strong base liquid ammonia or ether solvent for about 1 to 40 hours at a temperature of about -80° to 125°C, and quench rapidly with water. followed by acid hydrolysis and when desired the free base is subjected to subsequent treatment with a base. |
| priorityDate | 1978-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.