http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-479576-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J33-007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0016 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J11-00 |
| filingDate | 1979-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1979-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-479576-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF 4-AZA-5-ANDOSTRAN-3 ONA 17 REPLACED. |
| abstract | A process for the preparation of substituted 4-aza-5alpha-androstan-3-one 17, of formula: ** (Formula) ** which process comprises the following steps: 1) reacting pregnenolone with iodine and pyridine to form the corresponding 20-pyridinium iodide derivative of pregnenolone; 2) reacting the product of step (1) with methanol to form the methyl ester of 17-carboxyandrostenol; 3) treating the product of step (2) with aluminum isopropoxide and cyclohexanone to form methyl 4-androstan-3-one-17-carboxylate; 4) hydrolyzing the product of step (3) to form the corresponding 17-acid compound; 5) treating the product of step (4) with the oxalyl chloride complex; pyridine to form the corresponding 17-acid chloride compound; 6) treating the product of step (5) in situ with diethylamine to form 17beta-N, N-diethylcarbamoyl-4-androstan-3-one; 7) oxidizing the product of step (6) with sodium periodate and potassium permanganate in a terbutanol: water solvent system to form the corresponding 5-oco-3,5-dry-androstan-3-oic acid compound; 8) treating the product of step (7) with methylamine in ethylene glycol to form 17beta-N, N-diethylcarbamoyl-4-methyl-4-aza-5-androsten-3-one; 9) Hydrogenating the product of step (8) by treating it with hydrogen under catalytic conditions to form the final product, 17beta- N, N-diethylcarbamoyl-4-methyl-4-aza-5alpha-androstan-3-one. |
| priorityDate | 1978-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.