http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-479369-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 |
| filingDate | 1979-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1980-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-479369-A1 |
| titleOfInvention | METHOD FOR PREPARING NEW SPIRALS (DIHIDROBENZOFURAN-PIPE- RIDINAS AND -PIRROLIDINAS. |
| abstract | 1. Method for preparing new spiro (dihydrobenzofuran-piperidines and -pyrrolidines) of formula I ** (Formula-01) ** or a pharmaceutically acceptable acid addition salt thereof, where X is hydrogen, nitro, amino, chlorine, fluorine, bromine, or methoxy; R is hydrogen, alcohol, alkenyl, unsubstituted or substituted phenyalkyl, cycloalkylalkyl, alkoxycarbonyl, or phenoxycarbonyl; and n is the integer 1 or 2, comprising; a) reacting a compound of formula ** (Formula-02) ** where X is as defined above and R is alcohol, alkenyl, cycloalkyl or phenyalkyl, with a non-nucleophilic base, in the presence of a solvent, at a temperature from 25 ° C to the reflux point of the reaction mixture, yielding a compound of formula I where X and n are as defined above, and R is alcohol, alkenyl, cycloalkyl or phenyalkyl; and b) optionally treating the compound thus obtained with an alcoholyl chloroformate or a phenyl chloroformate, providing a compound of formula I where X and n are as defined above, and R is alkoxycarbonyl or phenoxycarbonyl; and c) optionally reacting the compound thus obtained with a base or an acid, providing a compound of formula I where X and n are as defined above, and R is hydrogen. |
| priorityDate | 1978-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.