| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb75b0b19820e3833ebdcb31603b242b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D505-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-00 |
| filingDate |
1978-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
1979-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-469286-A1 |
| titleOfInvention |
A PROCEDURE FOR PREPARING ARYLMALONAMIDE-1-OXADESTIACEFALOSPORINS SALTS |
| abstract |
Several 1-oxadethicephalo sporins closely related to the known (1-thia)-cephalo sporins have now been prepared in the present invention. Contrary to reports suggesting that their racemic 1-oxacephalo sporins exhibited about half the potency of (1-thia)cephalo sporins, the optically active products prepared in the present invention were about 4 to 8 times more active. than the corresponding (1-thia)cephalo sporins in terms of their antibacterial properties. However, the beta-lactam ring of the 1-oxadethicephalo sporins was less stable for use as clinical drugs than that of the (1-thia) cephalo sporins. The compounds selected from among the optically active compounds prepared in the present invention, solve the aforementioned deficiency of 1-oxadesticephalo sporins. |
| priorityDate |
1976-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |