| abstract |
Preparation of compounds which are reacted with an aldehyde of the formula R-CHO (R has the meaning given above) with a salt of the hydrazine derivative H2N-NH-R'', in particular with aminoguanidine sulfate or with hydrobromide hydrazinoimidazoline, in a polar organic solvent, at solvent reflux. The organic solvent is preferably a lower alcohol, in particular methanol or ethanol or ethylene glycol, optionally mixed with water. Compounds (I) have pharmacological properties that make them very useful in therapeutics. They are mainly active on the cardiovascular system. |