http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-451452-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c6160edd52eda4077bde8adf1f8ff28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 |
| filingDate | 1976-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-451452-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF NEW HI-DRUG DERIVATIVES OF 1-OXO-ISOINDOLINE. |
| abstract | A process for the preparation of new hydrogenated derivatives of 1-oxo-isoindoline, characterized in that compounds of formula (I) are prepared: ** (See formula) ** where A represents a cyclohexane ring that is saturated or contains 1 or 2 unconjugated carbon-carbon double bonds; R represents a hydrogen atom or an alkyl group of 1, 2 or 3 carbon atoms and B represents a hydroxyl group, the group -OR1 (where R1 represents an alkyl group of 1, 2 or 3 carbon atoms) or the group -NR2R3 (where R2 and R3 are the same or different and each represents an atom of hydrogen or an alkyl group of 1, 2 or 3 carbon atoms or R2 and R3, together with the nitrogen atom to which they are attached, form a non-aromatic heterocyclic group) and pharmaceutically acceptable salts thereof, by: (a) reducing a 1,3-dioxy-isoindoline derivative of general formula (II): ** (See formula) ** (where A, R and B are those already defined) or the corresponding nitrile where the -CO-B group is replaced by a nitrile group, with a borohydride to produce a 3-hydroxy-1-oxo-isoindoline derivative of formula (III): ** (See formula) ** (where A, R and B are as defined above) or the corresponding nitrile where the group -CO-B is replaced by a nitrile group; (b) reduction or dehydration of said compound (III) when B represents a hydroxyl group, -OR1 group or -NR2R3 group or hydrolysis of said compound (III) when B represents -OR1 group or -NR2R3 group or when the -CO-B group is replaced by a nitrile group and (c) optionally salification of the resulting compound of formula (I). (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1975-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.