http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-450888-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a965400e3c55bc849464b71324c5317 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1976-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-450888-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING A DERIVATIVE OF 1-BENZYL-3- (3- (DIMETHYLAMINE) PROPOXI) -1H-INDAZOLE. |
| abstract | Procedure for obtaining a 1-benzyl-3-3- (dimethylamino) propoxy-1H-indazole derivative of structure: ** (see formula) ** Characterized in that it is carried out in six steps as described below: In the first step the methyl ester of anthranilic acid is mixed with benzyl chloride and anhydrous sodium acetate, obtaining the methyl ester of h-benzylantranilic acid. In the second step, the anthranilic acid derivative in hydrochloric acid and chloroform is treated with concentrated sodium nitrite solution, obtaining 1-benzyl-3-hydroxy1H-indazole. In the third step, 1-benzyl-3-hydroxy-1H-indazole in anhydrous acetone and anhydrous potassium carbonate is reacted with 3-chloropropanol, obtaining the corresponding 1-benzyl 3- [3-hydroxypropoxy] -1H-indazole. In the fourth step, the 1-benzyl-3- [3-hydroxypropoxy] -1H-indazole is reacted with the p-toluenesulfoniyl chloride in pyridine, obtaining 1-benzyl-3- [3-tosyloxypropoxy] -1H -indazol. In the fifth step, the corresponding tosyl derivative of indazole reacts with dimethylamine, yielding 1-benzyl-3- [3- (dimethylamine) propoxy] -1H-indazole. In the sixth and last step, a solution of O-hydroxybenzcic in ethyl acetate is mixed with another one of 1-benzyl 3- [3- (dimethylamino) propoxy] -1-h-indazole in the same solvent obtaining the final product. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1976-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.