http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-446571-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1976-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-446571-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF VIMBLASTIN, LEUROSIDINE AND LEUROCRISTINE. |
| abstract | A procedure for the preparation of vinblastine, leurosidine and leurocristine derivatives of the formula: ** (See formula) ** or its pharmaceutically acceptable acid addition salts where R is NH-alq-X, NH-cycloalq- (C3-C8), NH-alq- (OH) 1-3 or N3, where alq is (C1-C6) alkyl, Am is NH2, NH-CH3 or N (CH3) 2 and X is hydrogen, cyano, phenyl, carboxyl, carboalkoxy- (C1-C3) or carboxamido; R1 is hydrogen or acetyl; R'' is hydrogen, (C1-C3) alkyl, formyl or (C1-C3) alkanoyl; and one of the radicals R'''or R''''is hydroxyl and the other is ethyl; whose process is characterized by reacting a compound of Formula I where R is NH-NH2, R'is hydrogen or acetyl and R'', R''' and R'''' are those defined above, with a nitrosating agent to form an azide and, if desired, react the azide with a compound of formula ** (See formula) ** where R2 is H or -CH3 and R3 is CH3, alq-X, cycloalq (C3-C8), alq-Am or alq (OH) 1-3, where alq is (C1-C6) alkyl and Am and X are the defined above and, if desired, react any of the products obtained above with a non-toxic organic or inorganic acid to form the acid addition salt of the product. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1973-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.