http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-445381-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C265-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C53-21 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C53-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-06 |
| filingDate | 1976-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-445381-A1 |
| titleOfInvention | A PROCEDURE OF ASYMMETRICAL CONVERTING 2-DEUTERO-3-FLUOR-1-ALANINE INTO THE CORRESPONDING ISOMER D. |
| abstract | 2-Deutero-3-fluoro-L-alanine is converted into its D-isomer in an asymmetrical manner. In this process, the L-isomer is reacted with sodium nitrite to give the corresponding L-2-deutero-2-halo-3-fluoro-propionic acid in solution in an aqueous hydrohalic acid. This L-2-deutero-2-halo-3-fluoropropionic acid is then reacted either with ammonia or with sodium azide with replacement of the 2-halogen substituent by a 2-azido group and subsequent catalytic hydrogenation to give 2-deutero-3-fluoro-D-alanine. 2-Deutero-3-fluoro-L-alanine can be converted into pharmaceutically acceptable salts. The resulting compound can be used for inhibition of the growth of Gram-positive and Gram-negative pathogenic bacteria. |
| priorityDate | 1975-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.