http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-445148-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-24 |
| filingDate | 1976-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-445148-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW THIAZOLIC DERVATES. |
| abstract | Procedure for the preparation of new thiazolic derivatives of general formula I: **(See formula)** in which R represents an alcohol radical containing from 1 to 5 carbon atoms, z represents a linear, saturated, aliphatic hydrocarbon chain of the formula: - (CH2) n- where n is an integer from 1 to 6, or an unsaturated aliphatic hydrocarbon chain of the formula: -CH = CH- or -CH = CH-CH = CH- and R1 represents a hydrogen atom or an alcohol radical containing from 1 to 5 carbon atoms, and its addition salts with strong mineral or organic acids or its alkaline, alkaline earth and aluminum salts, characterized in that: either, to obtain the products of formula I, in which Z represents: - (CH2) n- An alcoholylthioamide of formula II is reacted: **(See formula)** in which R represents an alcohol radical containing from 1 to 5 carbon atoms, with a product of formula III: **(See formula)** in which hal represents a chlorine or bromine atom, Z has the meaning given above and represents an alcohol radical containing from 1 to 5 carbon atoms, obtaining a product of formula I, in which R1 represents a alcohol radical containing from 1 to 5 carbon atoms which, if desired, hydrolyzes to obtain a corresponding product of formula I, in which R1 represents a hydrogen atom which, if desired, is treated with an alcohol of formula : R'1OH in which R'1 represents an alcohol radical containing from 1 to 5 carbon atoms, to obtain the corresponding ester of formula I; either, to obtain the products of formula I, in which Z represents: -CH = CH- or -CH = CH-CH = CH- a product of formula IV is reacted: **(See formula)** in which R has the meaning already given, or with malonic acid in the presence of a basic agent, to obtain a product of formula I, in which Z represents: -CH = CH- and R1 represents a hydrogen atom which, if desired, is treated with an alcohol of the formula: R'1OH in which R'1 represents an alcoholic radical containing from 1 to 5 carbon atoms, to obtain the corresponding ester of formula I, or with an alcoholic dialcohilfosfonocrotonate of formula V: **(See formula)** in which R'1 represents an alcoholic radical containing from 1 to 5 carbon atoms and alc represents an alcoholic radical containing from 1 to 3 carbon atoms, to obtain a product of formula I, in which Z represents: -CH = CH-CH = CH- and R1 represents an alcohol radical containing from 1 to 5 carbon atoms which, if desired, hydrolyzes to obtain a product of formula I, in which R1 represents a hydrogen atom which, if desired, is treated with a formula alcohol: R'1OH in which R'1 represents an alcohol radical containing from 1 to 5 carbon atoms, to obtain the corresponding ester of formula I; and, if desired, the product of formula I is reacted with a strong mineral or organic acid or, when R1 represents a hydrogen atom, with the corresponding base. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1975-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 24.