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filingDate 1976-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1977-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-444398-A1
titleOfInvention A PROCEDURE FOR PREPARING O-MEGA-PENTANORPROSTAGLANDINS INTERMEDIATE COMPOUNDS.
abstract A procedure for preparing intermediate compounds of ω -pentanorprostaglandins of the formula: **(See formula)** and its epimer at C15; wherein A is 1-adamantyl, 2-norbornyl, 2- (l, 2,3,4-tetrahydronaphthyl) where said group is racemic or optically active, 2-indanyl or substituted 2-indanyl where said substituent it is halogen, trifluoromethyl, alcohol of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; R is hydrogen or C 1 -C 4 alcohol; n is an integer from 0 to 5; W is a single bond or a cis double bond; 2 is a single bond or trans double bond; THP 2-tetrahydropyranyl; X is (a) a group of the formula (see formula) in which R'is hydrogen, alcohol of 1 to 10 carbon atoms; aralkohyl of 7 to 9 carbon atoms; cycloalkoxy of 3 to 8 carbon atoms; α-0 β-naphthyl; 5-indanyl; phenyl or monosubstituted phenyl, wherein said substituent is halogen, alcohol of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or phenyl; (b) 5-tetrazolyl; or (c) a group of the formula (see formula) in which R'' is alkanoyl having from 2 to 10 carbon atoms or cycloalkanoyl having from 4 to 8 carbon atoms; aroyl or aroyl substituted from 7 to 11 carbon atoms in which said substituent is methyl, halogen or methoxy; alkylsulfonyl of 1 to 7 carbon atoms; arylsulfonyl or substituted arylsulfonyl wherein said substituent is methyl, halogen or methoxy; characterized in that it comprises reacting, under anhydrous conditions, a compound of the formula **(See formula)** wherein A, R, n, THP and Z are as defined above, with an ilide formed from (see formula), where R'and X are as defined above, in dimethyl sulfoxide as solvent and at a temperature comprised within the range of -20º to + 40ºC. (Machine-translation by Google Translate, not legally binding)
priorityDate 1972-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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