http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-441141-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2422dc3103d68c8b23c089bafa4ba0fa |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1975-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-441141-A1 |
| titleOfInvention | A PROCEDURE FOR OBTAINING 1, 4, 5-TRIMETHYL-2- (3, 4, 5-TRIMETOXIBENCIL) -1, 2, 3, 6-TETRAHIDROPIRIDINA. |
| abstract | A process for the preparation of 1,4,5-trimethyl-2- (3,4,5-trimethoxybenzyl) -l, 2,3,6-tetrahydropyridine of formula i ** (see formula) ** And its addition salts with pharmacologically acceptable acids, for example the hydrohalic acids, characterized in that in a first synthesis step, 3,4-trimethoxybenzaldehyde is reacted with a mixture of 2-bromo-3,4-dimethylpyridine and 2- bromine-4, 5-dimethylpyridine obtained from 3,4-lutidine by the successive action of sodium amide and sodium nitrite in the presence of bromine and hydrobromic acid, resulting in a mixture of 3, 4, 5 trimethoxyphenyl- (3,4-dimethyl-2-pyridyl) carbinol and 3,4,5-trimethoxyphenyl- (4,5-dimothyl-2-pyridyl) carbinol of the formulas ii 'and ii ** (see formula) ** From which the last component is separated by column chromatography, which is reacted at a temperature lower than 20ยบ c. With thionyl chloride, and then dissolved in an acid medium, with zinc powder to give the 2- (3, 4, 5-trimotoxiboncil) -4,4-dimotypyridine of the formula iii, ** (see formula) ** Which treated with methyl iodide provides the 2- (3,4,5-trimethoxybenzyl) -4,5-dimethylpyridinium iodide of the formula iv ** (see formula) ** Which in a final synthesis step is reduced with boron tetrahydride and sodium to 1, 4, 5-trimethyl-2- (3, 4, 5-trimethoxybenzyl) -l, 2, 3, 6-tetrahydropyridine (I) which, if desired, is converted into its addition salts with pharmacologically acceptable acids, for example the halohydrates. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1975-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.