http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-438998-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20d25237fd0ab5071fb92f675f32aaa1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1975-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-438998-A3 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF 7- (D-ALPHA-AMINO-PHENYLACETAMIDE) -3-DEACETOXYCEPHALOSPORANIC ACID. |
| abstract | Process for the preparation of 7- (d-alpha-amino-phenylacetamido) -3-deacetoxycephalosporanic acid of formula ** (see formula) ** Where n is 0, 1, 2 or 3, characterized because: in a first phase, A) the 7-aminodesacetoxycephalosporanic acid of formula iid is reacted with trimethylchlorosilane or dimethylchlorosilane or with chloromethyl pivalate in methylene chloride or chloroform, in the presence of amine compounds of the triethylamine and dimethylaniline type, diethylaniline, quinoline, isoquinoline or pyridine, at a temperature higher than 20ºC but lower than 60º c; in a second phase, B) the silylated derivative or the pivaloyloxymethyl ester of 7-aminodesacetoxycephalosporanic acid, resulting from the previous step, is reacted with d-phenylglycine chloride hydrochloride, likewise in the presence of dimethylaniline, diethylaniline, quinoline, isoquinoline or pyridine; in a third phase, C) the sealed derivative or the pivaloyloxymethyl ester of cefalexin, formed in the previous phase, is hydrolyzed by the addition of water at a ph of 1.0 to 1.5; D) by following the phases in which the raw cephalexin is isolated directly by the addition of ammonia or triethylamine to a ph of 3.5 to 4.5 and E) in which the cefalexina is purified by suspending it in water at a temperature of 50 to 70º c. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1975-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.