http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-437778-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F- |
| filingDate | 1975-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-437778-A1 |
| titleOfInvention | PROCEDURE FOR THE PRODUCTION OF ARALKYLAMINES. |
| abstract | Procedure for the production of group aralkylamines: such of formula 1 **(See formula)** and its physiologically tolerable mono and polybasic acid addition salts, characterized in that a) halogen, alkyl- or arylsulfonyloxy compounds and B) amines are reacted, corresponding a) component a) to formula II R1-CH2-X and component B) to formula III **(See formula)** b) component a) to formula IV **(See formula)** and component B) to formula V **(See formula)** or c) component A) to formula VI X-R3 and component B) to formula VII **(See formula)** or d) the acid amides of formulas X to XIII are subjected to reduction **(See formula)** e) amines of the formula VII, for example with alkyl esters of sulfuric acid, are subjected to the acylation itself, f) a compound of the formula II is reacted, in which X is an aldehyde group, with aminoheptane of formula III, which is then reduced in a manner known per se, representing in the formulas R1 is a substituted phenyl radical containing as substituents 2 to 4 the same or different alkyl radicals with 1 to 4, but with a total of not more than 6 carbon atoms, the alkyl substituents being, optionally located in the para position, separated from minus one other alkyl radical per one ring C atom, or containing 1 or 2 halogen atoms or nitro groups, the fluorine substituents possibly present being arranged in the para position and, having two halogen substituents, these are arranged in the ortho position only, the aforementioned positions for and referring each time to the substituted aminomethylene group; R2 is an alkyl radical branched or not with 4 to 10 carbon atoms, but at least 4 in a chain, the chain being in the form of an unbroken alkyl chain and/or an alkyl chain substituted by a hydroxyl group, and a) eventual branching occurring in the β position in relation to the N atom only together with at least one further branching, and b) the alkyl chain containing at least three branches, and c) being a unique alkyl radical in the alpha position with respect to the N atom always methyl, and R3 a hydrogen atom or an alkyl radical with 1 to 4 carbon atoms which may be substituted by a dialkyl phosphonyl group of the formula **(See formula)** in which R4 and R5 each signify an alkyl radical with a total of 2 to 6 carbon atoms, but R3 in cases c) and e) is not hydrogen, and R6 has the same meaning as R2, but one C atom less than R2; R7 represents an alkyl radical with up to 3 carbon atoms that can be substituted by a dialkyl-phosphinyl group of the formula **(See formula)** and X a halogen, alkylsulfonyloxy or arylsulfonyloxy group, and the compounds obtained are isolated as such or reacted with physiologically tolerable acids to form acid addition compounds. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1975-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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