http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-436883-A1

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filingDate 1975-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1977-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-436883-A1
titleOfInvention PROCEDURE FOR THE PREPARATION OF NEW ALKANOLAMINE DERIVATIVES AND ITS OPTICAL ISOMERS.
abstract Procedure for preparing new alkanolamine derivatives and their optical isomers of general formula I: ** (See formula) ** where: n represents 2 or 3 - R1 and R2, which may be identical or different, each represent an alkyl radical containing from 1 to 4 straight or branched chain carbon atoms, or - R1 and R2 form with the nitrogen atom to which they are attached a radical pyrrolidinyl, piperidino, dimethylpiperidino, morfolino, tio-l-morfolino, azabicyclo [3,3 0] octyl or azabicyclo [3,2,2] nonyl, as well as its addition salts with mineral or organic acids, characterized by: - or a dl, d or l N- (l-trifluoromethylphenyl 2-propyl) N-benzylglycine of general formula II is reacted: ** (See formula) ** with an aminoalkanol of general formula III: ** (See formula) ** where R1, R2 and n have the meanings given above and the dl, d or l glycinate thus obtained of general formula IV is then subjected to a hydrogenation: ** (See formula) ** wherein R1, R2 and n have the meanings given above, in order to remove the benzyl group, - or else an ethyl dl, d or l N- (l-trifluoromethylphenyl-2-propyl) glycinate of general formula V is reacted: ** (See formula) ** with an aminoalkanol of general formula III, as defined above, and if desired, the derivatives of general formula I thus obtained are treated with compatible acids to give the corresponding acid addition salts. (Machine-translation by Google Translate, not legally binding)
priorityDate 1974-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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