http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-435757-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e15db293ae56fc92907cfb7431749dc6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 1975-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-435757-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF AROMATIC AMIDES OF HETEROCICLIC COMPOUNDS. |
| abstract | Procedure for the preparation of aromatic amides of heterocyclic compounds of general structure (I) in the form of N-oxides **(See formula)** being: R = a lower (C1-C6) alkoxy or lower alkenoxy (C2-C6) group; R1 and R2, which may be different from each other, are hydrogen, halogen, sulfonamido, amino, alkyl- or dialkylamino lower (C1-C6), alkylsulfonyl, alkyl sulfonamido or acylamino groups, the radical R1 being substituted in position 3 or 4 of the aromatic ring; R3 is hydrogen, a lower alkyl or aryl group; Ar is aryl, aroyl, or a simple aromatic heterocycle; x is zero or one; y is 2 or 3; z is a number from 1 to 6; the acylamino group may be present as radical R1 or R2 or both at the same time, or represented by the formula R4CONH where R4 is hydrogen, lower alkyl, mono-, di- or trisubstituted haloalkyl, or an amino- or amino-substituted alkyl, So R4 is (see formula) where: R5 and R6 are hydrogen, lower alkyl (C1-C6), aryl alkyl or together with the nitrogen atom can form a 5-, 6- or 7-membered ring, which may or may not contain, an additional heteroatom; each of the aryl, clay or single aromatic heterocycle groups represented by the radical R3 or Ar may be substituted with 1 to 3 the same or different groups selected from the following; C1-C6 alkoxy, hydroxyl, amino, mono- or dialkyl-substituted amino, nitro, halogen (fluoro, chloro or bromo) trifluoromethyl, C1-C6 straight or branched chain alkyl, or sulfonamido; the simple aromatic heterocycle groups of the Ar radical can contain one or more heterotherms, such as thiophene; characterized in that the reaction between the aromatic amides of general structure (I) is carried out with an oxidizing agent to give the N-oxides of structure (II) **(See formula)** R, R1, R2, R3, x and z being what has been previously defined, using as oxidizing agents organic peroxides or hydrogen peroxide, and an organic acid such as formic or acetic, at a temperature of 40-100ºC and using acetic acid as solvent. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1974-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.