http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-435560-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5922cbe7c65a9136f85906fa09e7c967 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-86 |
| filingDate | 1975-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-435560-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF NEW SUBSTITUTED XANTONE-CARBOXYL ACIDS COMPOUNDS. |
| abstract | A procedure for the preparation of new compounds of xanthone-substituted carboxylic acids selected from those represented by the formulas: **(See formula)** and its non-toxic and pharmaceutically acceptable esters, amides and salts; where R is hydrogen or lower alkyl, the procedure of which consists of: 1) condensing an o- or p-substituted phenol, where the substituent is hydroxy or lower alkoxy, with a 1,3-dicarboalkoxy-4-halobenzene in the presence of cuprous oxide to give the corresponding 1,3-dicarboalkoxy-4- (phenyloxy o- or p-substituted) benzene, hydrolyze the latter in basic medium to give the corresponding 1,3-dicarboxy-4- (phenyloxy o- or p-substituted) benzene and cycle the latter to give the corresponding xanthone-2 acid 5 or 7-substituted carboxylic; 2) converting any 5- or 7-lower alkoxy-xanthone-2-carboxylic acid from step 1) to the corresponding 5- or 7-hydroxy compound; 3) convert any 5- or 7-hydroxyxanthone-2-carboxylic acid from steps 1) and 2) to their lower alkyl esters; 4) treating a 5- or 7-hydroxyxanthone-2-carboxylic acid ester from step 3) with a dialkylthiocarbamoyl chloride in the presence of a base, transpose the obtained product and hydrolyze the transposed product in basic medium to give the corresponding acids 5- or 7-mercaptoxanthone-2-carboxylic; 5) optionally treating the product from step 4) with an alkyl halide in the presence of a base, optionally followed by hydrolysis and 6) optionally converting a product from step 4) to its corresponding pharmaceutically acceptable, non-toxic esters, amides and salts. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1971-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.