| abstract |
Procedure to prepare ureidotetralin compounds, of formula: **(See formula)** wherein R3 is hydrogen, C1 to C4 alkyl, or hydroxy; R6 and R'6 are each hydrogen or each is methyl; R7 is hydrogen, amino, chloro, cyano, C1 to C4 alkyl or C1 to C4 alkoxy; R8 is hydrogen, chlorine, C1 to C4 alkyl or C1 to C4 alkoxy; R9 is hydrogen, chlorine, C1 to C4 alkyl, C1 to C4 alkoxy, acetamido or -NH-CO-NHR11, where R11 is allyl, C1 to C12 alkyl or hydrogen; R10 is hydrogen, C1 to C4 alkoxy or C1 to C4 alkyl; with the proviso that at least one of R3, R6, R7, R8, R9, and R10 is a member other than hydrogen, and that no more than four of R6, R7, R8, R9, and R10 are members other than hydrogen; characterized by comprising reacting approximately 1 to 2 molar equivalents of isocyanic acid, which is formed in situ, by the reaction of hydrochloric acid and potassium cyanate, with approximately 1 molar equivalent of a compound having the structure: **(See formula)** wherein R3, R6, R7, R8, R9 and R10 are as described above, in water or in an aqueous alcohol mixture of C1 to C4, at a temperature between about 0ºC and 80ºC. (Machine-translation by Google Translate, not legally binding) |