http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-433299-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b9f373878f16dc291ff597162e9b344 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-80 |
| filingDate | 1974-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-433299-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW BENZOPYRANE DERIVATIVES. |
| abstract | Procedure for the preparation of new benzopyran derivatives, which have the general formula (I) **(See formula)** in which the symbol (see graphic) represents a double or single bond; one of the radicals R1 and R3 is an amine, unsubstituted or mono- or di-alkyl-substituted group or a heteromonocyclic radical containing, optionally, another heteroatom chosen from the group consisting of N, O, S and the other is hydrogen or a unsubstituted or mono-di-alkyl-substituted amine group or a heteromonocyclic radical as indicated above; each of the radicals R2 and R4, the same or different, can be hydrogen, halogen, hydroxyl, alkyl, alkoxy or trifluoromethyl; X can be (see formula), wherein R5 and R6 can be hydrogen or alkyl, and a respective pharmaceutically acceptable salt; with the exclusion of the following compounds: - 2-amino-6-oxo-6H-dibenzo [b, d] pyran, - 3-amino-6-oxo-6H-dibenzo [b, d] pyran, - 8-amino-6-oxo-6H-dibenzo [b, d] pyran, - 3-amino-8-methoxy-6-oxo-6H-dibenzo [b, d] pyran, - 3-amino-6-oxo-7,8,9,10-tetrahydro-6H-dibenzo [b, d] pyran, - 9-methyl-3-dimethylamino-6-oxo-7,8,9,10-tetrahydro-6H-dibenzo [b, d] pyran, - 3-dialkylamino-6-oxo-7,8,9,10-tetrahydro-6H-dibenzo- [b, d] pyran, characterized by reacting a compound of formula (II) **(See formula)** in which R3 and R4 have the meaning indicated above and R7 is an alkyl group, with a compound of the formula (III) **(See formula)** in which R1 and R2 have the meaning indicated above and R is hydrogen or alkyl, to obtain a compound of formula (I) where X is (see formula) and the symbol (see graph) represents a single bond and, if desired, dehydrogenating the compound of formula (I), thus obtained, to provide a compound of formula (I) where the symbol (see graph) represents a double bond and/or, if desired, reduce a compound of formula (I) where X is (see formula) to a compound of formula (I) where X is -CH2- and/or if desired, convert a compound of formula (I), where X is (see formula) in a compound of formula (I) where X is (see formula), where R5 and R6 are alkyl groups, by means of a Grignard reaction. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1973-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 15.