http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-430111-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f78161122995a1943e5bd9c9e76a04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1974-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-430111-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF NEW COMPOUNDS DEBIGUANIDA SUBSTITUTED WITH PHENYL. |
| abstract | A procedure for the preparation of new phenyl-substituted biguanide compounds corresponding to one of the formulas **(See formula)** where n is 1-3; Alc, Hal and R can be in any position in the ring; Alc is lower alcohol or lower alkenyl of 1 to 7 carbon atoms, which can be straight chain or branched; Hal is fluoro, chloro, bromo or iodo; and R is Hydrogen, fluoro, chloro, bromo, iodo or lower alcohol of 1 to 7 carbon atoms that can be straight chain or branched; with the proviso that Alc is other than 2-methyl when Hal is chlorine or 4-bromine at the same time that R is Hydrogen or when Hal and R are 3,5-dichloro; and Alc is other than 4-methyl or 4-butyl when Hal is 3-chloro and R is hydrogen; and its non-toxic acid addition salts; X, Y and Z can be in any position on the ring; X and Y are fluoro, chloro, bromo or iodo; with the proviso that X or Y is other than 2-bromine when Y or X remaining is 4-chloro or 4-bromine while Z is hydrogen; and, when X and Y are both chlorine and are in a position other than 2 and 6, Z is then other than hydrogen; and when X, Y and Z are all chlorine and X and Y are in positions 3 and 4, Z is then in position 2; X'is 2-trifluoromethyl when Y' is halo, nitro, or trifluoromethyl; 3-trifluoromethyl when Y'is halo, nitro, or trifluoromethyl provided that Y' is other than 4-halo or 4-nitro; 4-trifluoromethyl when Y'is nitro or trifluoromethyl; and Hydrogen when Y'is trifluoromethoxy, difluoroacetyl, trifluoroacetyl or trifluorosulfonyl, a process in which cyanoguanidine and a substituted aniline of the formulas are condensed **(See formula)** where n, Alc, Hal, R, X, Y, Z, X'and Y' are as previously described, in the presence of an acid. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1971-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.