http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-427480-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C02F1-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1974-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-427480-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF AN INHALATION AGENT CONTAINING CORTICOIDS. |
| abstract | Procedure for the preparation of an inhalation agent containing corticosteroids, characterized in that a corticoid of the general formula I is prepared as an active substance **(See formula)** where -BA- means the -CH2-CH2-, -CH = CH- or -CCl = CH- groupings, X means a hydrogen atom, a fluorine atom or a methyl group, Y means a hydrogen atom, a fluorine atom or a chlorine atom, Z means a methylene group, a hydroxymethylan group, a fluoromethylene group, a cloxaroethylene group or a corbonyl group, R1 means a hydrogen atom or a methyl group, and R2 means a hydrogen atom or R1 and R2 together signify an isopropylidenedioxy group; and R3 signifies a hydrocarbon radical with 1 to 12 carbon atoms, a) oxidizing the 20-hydroxy group of compounds of the general formula II **(See formula)** where -AB-, X, Y, Z, R'1, R2 and R2 have the same meanings as in formula I, if desired by oxidizing a free hydroxy group present at position 11, and if desired by saponifying or transesterifying the 21-esters of the general formula I, and transforming into their salts or esterifying the free acids of the general formula I; or b) oxidizing the steroid-aldehydes of the general formula III **(See formula)** where -AB, X, Y, Z, R1 and R2 have the aforementioned meanings or the hydrates, hemiacetals or acetals of these compounds in the presence of alcohols and cyanide ions, with oxides of heavy metals with oxidizing action, if desired oxidizing a free hydroxy group present at position 11, saponifying or transesterifying, if desired, the 21-esters of the general formula I, and transforming into their salts or esterifying the free acids of the general formula I; or c) for the preparation of compounds of the general formula I in which -A-B- has the meaning of a group -CH = CH-, dehydrogenating the compounds of the general formula IV, **(See formula)** where X, Y, Z, R1, R2 and R3 have the aforementioned meanings, if desired by oxidizing a free hydroxy group present in position 11, saponifying or transesterifying eventually the 21-esters of the general formula I, and transforming into their salts or esterifying the free acids of the general formula I; and bringing the corticosteroid of the general formula I thus obtained into a form suitable for inhalation. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1973-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.