http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-423531-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-59 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 |
| filingDate | 1974-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-423531-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF ALPHA-AMINOACIL-3- HALO-CEPHALOSPORIN. |
| abstract | A procedure for the preparation of α-aminoacyl 3-halo-cephalosporin of the formula: **(See formula)** where R is phenyl, hydroxyphenyl, halophenyl, methylphenyl, methoxyphenyl, 2-thienyl, 3-thienyl or 2-furyl; R1 is hydrogen, benzyl, p-methoxybenzyl, p-nitrobenzyl, diphenylmethyl, 2,2,2-trichlorethyl, trimethylsilyl or tert-butyl; R2 is hydrogen or tert-butyloxycarbonyl, benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, trichloroethoxycarbonyl or trityl, or enamines formed with methyl acetoacetate and acetylacetone; X is chlorine or bromine; and its non-toxic and pharmaceutically acceptable salts; whose procedure is characterized by: a) reacting a 3-halo-3-cephemic ester of the formula: **(See formula)** where R1 and X are as defined above, with an acylating agent of the formula: **(See formula)** or an active derivative thereof, to give the corresponding 7- (α-amino) or 7- (protected α-amino) acylamido-3-halo-3-cephem-4-carboxylic acid ester and b) optionally removing the carboxylic acid protecting ester forming group or amino protecting group to give the corresponding 7- (α-amino) acylamido-3-halo-3-cephem-4-carboxylic acid. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1973-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.