http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-422450-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-194 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-194 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 |
| filingDate | 1974-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-422450-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW IMIDAZO (4,5-B) PYRIDINES. |
| abstract | Procedure for the preparation of new imidazo [4,5-b] pyridines of the general formula I **(See formula)** and of its isomers of the general formula Ia **(See formula)** in which R1, R2 and R3, which may be the same or different, signify hydrogen or halogen atoms, hydroxy, alcoholic, allyloxy, benzyloxy, alcoholylthio, alcoholylsulfinyl, alcoholylsulfonyl groups, amino groups optionally substituted with alcohol radicals, alkoxy radicals with 1 to 4 carbon atoms, optionally substituted with a halogen atom, with a hydroxy, alkoxy, alcoholylthio, alcoholilsulfinyl, alcoholylsulfonyl, alkylamino, dialkoxylamino, piperidino, morpholino, thiomorpholino, 4-alcoholylpiperazino, 4-dimethoxyphenylpipeino, phenylethylpiperazine, phenylethylamino, N-methylphenylethylamino or N-methyldimethoxyphenylethylamino, morpholino or piperazino radicals which at position 4 are substituted with a phenyl or alcohol radical with 1 to 3 carbon atoms, or two of the radicals R1 to R3 together signify the group methylenedioxy, not being able to represent any hydrogen atom at least one of the radicals R1 to R3, in case R4 means Make one hydrogen atom, and each of the above-mentioned alcohol radicals can contain 1 to 4 carbon atoms; where at least one of the radicals R1, R2 or R3 must have a different meaning from a hydrogen or halogen atom, an amino or methyl group, R4 means a hydrogen atom, an alcohol radical possibly substituted with a hydroxy, dialcoylamino, phenyl group, dimethoxyphenyl, piperidine, morpholino, 4-methylpiperazine or 4-phenylpiperazine, each of the aforementioned alcohol radicals containing 1 to 4 carbon atoms, or a phenyl radical optionally substituted with halogen atoms or methoxy groups; and R5 signifies a hydrogen or halogen atom or a lower alcohol radical, as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a pyridine of the general formula II is reacted, **(See formula)** where R5 is as initially defined and Y represents a halogen atom or the group R4NH, where R4 is as initially defined, with a compound of general formula III, **(See formula)** in which R1 to R3 are as initially defined and X represents a carboxyl group or its functional derivative, and if desired a compound of the general formulas I or Ia thus obtained, which contains a halogen atom capable of reacting, is transformed with an amine into the corresponding amine compound, and/or a compound of the general formulas I or Ia thus obtained, which contains a hydrogen atom capable of reacting, is subjected to alcoholization in the presence of a base by means of or an agent of alcoholization, and/or a compound of the general formulas I or Ia thus obtained is transformed by an oxidizing agent into the corresponding compound of N-oxide, S-oxide or 3, S-dioxide, and/or is transformed into its salt by addition of acid physiologically compatible with an organic or inorganic acid. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1973-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.