http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-421353-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-96 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-04 |
| filingDate | 1973-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-421353-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF SPIROHETER-CYCLANIC COMPOUNDS THAT CARRY A PHENILACETIC GROUPING. |
| abstract | A process for the preparation of spiroheterocyclanic compounds bearing a phenylacetic group, of general formula i: Wherein x represents an oxygen atom, r represents a hydrogen atom or a linear or branched alkyl radical containing 1 to 4 carbon atoms and n equals 2, 3 or 4, as well as their esters and their salts with a mineral or organic base, these compounds being in racemic or optically active form when r is other than hydrogen, characterized in that a lower alkyl 4-tetrahydropyranylidene cyanacetate is reacted ** (see formula) ** In which the symbol "lower alkyl" represents a lower alkyl radical carrying from 1 to 6 carbon atoms, with paratolylmagnesium bromide, to obtain a lower alkyl-cyano-4- (p-methylphenyl) tetrahydropyran-4-acetate, of formula ** (see formula) ** On which a basic agent is made to act in an aqueous medium, and then an acid, to obtain the 4- (p-methylphenyl) tetrahydropyran-4-acetic acid of the formula ** (see formula) ** If desired, the acetic chain is extended with the aid of an approval agent, the resulting 4- (p-methylphenyl) tetrahydropyran-4-alkylcarboxylic acid of general formula is subjected to ** (see formula) ** To the action of a brominating agent, the resulting 4- (p-bromomethylphenyl) tetrahydropyran-4-alcoholcarboxylic acid is treated with an alkaline cyanide, of the general formula: ** (see formula) ** To obtain 4- (p-cyanomethylphenyl) tetrahi-dropiran-4-alkoxycarboxylic acid, of general formula ** (see formula) ** Whose nitrile function is hydrolyzed by the action of a basic agent, to obtain 4- (p-carboxymethylphenyl) tetrahydropyran-4-alkylcarboxylic acid, of general formula ** (see formula) ** This compound is subjected to the action of an acid cyclization agent to obtain the acid of general formula ** (see formula) ** This compound is treated with an agent, or a reducing system, and then the resulting acid of formula i is optionally subjected to r = h ** (see formula) ** To the action of a suitable esterification agent, to obtain an ester of general formula viii ** (see formula) ** Which is subjected to the action of an alkylating agent, and then to a hydrolysis, to obtain an acid of general formula ** (see formula) ** And the salts and esters of this acid are formed, if appropriate, according to known methods. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1970-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.