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filingDate 1973-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1976-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-419345-A1
titleOfInvention A METHOD FOR PREPARING OCTAHYDROARYLISOQUINOLEINS.
abstract A method of preparing octahydroarylisoquinoline of the formula **(See formula)** wherein (-A-B-) is alternatively (-CH2-NR1-); Z is selected from the group consisting of phenyl, substituted phenyl, naphthyl, and aromatic heterocycle; R1 and R2 are selected from the group consisting of hydrogen, lower alcohol, lower alkenyl, aryl-lower alcohol, aryl-lower alkenyl and heterocyclyl; X and Y are selected from the group consisting of hydrogen, carboxy, carboxyamido, lower carboalkoxy, carbonyl, nitro, hydroxy, cyano, amino, lower alcohol-amino, di-lower alcohol-amino, hydroxymethyl, lower acyloxy-methyl, lower alkoxy -methyl, aminomethyl, arylsulfonoxymethyl and halomethyl, and X and Y, taken together, are selected from the group consisting of **(See formula)** where Z1 is NH, NR, oxygen, sulfur, -CH = CH-, -CH2- or -CH2-CH2- and -CH2-Z2-CH2, where Z2 is oxygen, sulfur, -CH = CH-, -CH2-, -CH2-CH2-, -NH- and NR, where R is selected from the group consisting of lower alcohol, aryl and aryl-lower alcohol, and their pharmaceutically acceptable salts, characterized by reacting a compound of the formula **(See formula)** where -A-B- is as already defined, and where R1 is other than hydrogen, with a compound of the formula: to form a product of formula I in which R1 is other than hydrogen, and to reduce said product in which R1 is benzyl, to form a product of formula I in which R1 is hydrogen. (Machine-translation by Google Translate, not legally binding)
priorityDate 1972-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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