| abstract |
Procedure for obtaining prostanoic acid derivatives, of general formula: **(See formula)** where R1 is a carboxy radical, A is an ethylene or vinylene radical; R4 is an aryl, furyl or thionyl radical that is unsubstituted or substituted by halogen, nitro, phenyl or halophenyl atoms, alkyl, alkoxyalkyl, haloalkyl, alkoxy or acylamino radicals each having 1 to 4 carbon atoms, or dialkylamino radicals where each alkyl contains 1 to 3 carbon atoms; R2 is a hydroxy radical and R3 is a hydrogen atom; whose compound contains 0, 1 or 2 alkyl radicals of up to 4 carbon atoms as a substituent on carbon atoms 2, 3 or 4; and for those compounds where R1 is a carboxy radical, the pharmaceutically and veterinarily acceptable salts are provided; characterized by comprising the reaction of a lactol of the formula: **(See formula)** wherein A and R4 are defined as above, with a (4-carboxybutyl) triphenylphosphonium salt, optionally carrying O, 1 or 2 alkyl radicals of 1 to 4 carbon atoms on carbon atoms 2, 3 or 4, in presence of a strong base, after which the product is reacted with a base when the formation of a salt is desired. (Machine-translation by Google Translate, not legally binding) |