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filingDate 1972-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1976-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-410249-A1
titleOfInvention A PROCEDURE FOR THE PREPARATION OF HALOPHENYLTHIOACETAMIDOCEPHALOSPORANIC DERIVATIVES.
abstract A process for the preparation of halofenylthioacetamidocephalosporin derivatives of the formula: ** (see formula) ** Where z is hydrogen or fluorine, and when z is hydrogen x and y are hydrogen or chlorine, selected so that the phenyl ring is substituted with one or two chlorine atoms and so that when a single chlorine atom is present, it is in position 3 and when two chlorine atoms are present, they are in positions 3,4, 3,5 or 2,5; and when z is fluorine it is in the 3 or 4 position of the phenyl ring, and each of x and y is hydrogen or chlorine, so that when the phenyl ring is substituted with one or two chlorine atoms, one of which is in the 3 or 4 positions of the phenyl ring; R is hydrogen, 5-methyl-1,3,4-tiadiazolyl-2-tio, 1-methyl-5-tetrazolylthio, 1H-tetrazol-5-ylt, 5-phenyl-1,3,4-oxyadiazolyl-2- that, 5- (p-nitrofenyl) -1,3,4-oxadiazolyl-2-tio, 5- (p-methoxyphenyl) -1,3,4-oxadiazolyl-2-thio, carbamethoxy, methylcarbamoyloxy, thiomethyl, pyridine, azide or dithycarbamoyl and R'is hydrogen, dicyclohexylamine or a pharmaceutically acceptable cation; Whose procedure is characterized by: A) N-acylate a compound of formula ** (see formula) ** Where r and r'have the meaning defined above, with an acylating agent comprising an acid of formula ** (see formula) ** Or the corresponding acyl halide, anhydride or mixed anhydride, wherein x, y and z have the meaning given above; and optionally preparing the salts thereof. (Machine-translation by Google Translate, not legally binding)
priorityDate 1971-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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