| abstract |
A procedure for preparing 2-decarboxy-2- [tetrazol-5-yl] prostaglandins of the formula: **(See formula)** where R is selected from the group consisting of (see formula) -alpha-hydroxy and (see formula); R2 and R3 are hydrogen; R1 is selected from the group consisting of hydrogen and lower alkyl; Y is selected from the group consisting of a single bond and a trans double bond; X and Z are each single bonds or are cis double bonds, such that when Z is a cis double bond, X is a cis double bond and Y is a trans double bond; characterized by reacting a compound of formula I above, wherein R, R1, X, Y and Z are as defined above, and R2 and are tetrahydropyranyl, with aqueous acetic acid. (Machine-translation by Google Translate, not legally binding) |