http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-402483-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 1972-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-402483-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING THE DEXTRO-ROTARY FORM OF SUBSTITUTED TETRAHYDROQUINOLINES. |
| abstract | Procedure for obtaining the dextro-rotary form of substituted tetrahydroquinolines, of formula: **(See formula)** wherein R1 and R2 each represent hydrogen or a lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, alkanoyloxy-lower alkyl or lower cycloalkyl group, or together with the nitrogen atom to which they are attached, form a saturated heterocyclic group which may be further substituted by one or more lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or alkanoyloxy-lower alkyl groups; R3, R6 and R7 are each hydrogen or a lower alkyl group; it is a methyl, hydroxymethyl, lower alkoxy methyl, lower alkanoyloxy methyl or formyl group; it is a nitro or cyano or halogen group; and n is 1 or 2, characterized in that it comprises preparing an optically active acid addition salt of the racemic form of the compound, using molar equivalent medium of the appropriate optically active acid anion; separate the salt that crystallizes; recrystallize it from a suitable solvent; and converting it to the free base or a pharmaceutically acceptable acid addition salt of the desired counter-rotational form of the compound. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1971-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.