http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-396132-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c861864adc77085cb995f59557c7ef6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-02 |
| filingDate | 1971-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-396132-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF THE ALPHA-6-DEOXY-5-HYDROXYTHETRACICLINE METAPHOSPHORIC ACID COMPLEXES AND THE ALKALI-METALLIC SALTS OF THE SAME. |
| abstract | Alkali metal polyphosphate complexes of alpha -6-deoxy-5-hydroxytetracycline are prepared which have the formula (C22H24N2O8)z . (MePO3)x . (HPO3 )y in which Me is sodium or potassium, z = 1 to 5, x = 1 to 5, y = 1 to 5, x + y </= 6 and z </= y. The compounds are obtained by reacting metaphosphoric acid in an organic medium which is inert to the reaction with 1 to 5 mol of alpha -6-deoxy-5-hydroxytetracycline. The remaining free acid groups of the metaphosphoric acid are then neutralised with a methanolic or ethanolic solution of sodium hydroxide or potassium hydroxide in the stoichiometric quantity. The complex formed in this process is then precipitated by addition of a non-solvent which is inert to the reaction. Preferred compounds are the ethanol/water solvate of the complex of the formula C22H24N2O8 . NaPO3 . (HPO3)5 and C22H24N2O8 . (NaPO3)2 . (HPO3)4. The said compounds have an antibiotic activity, and they are very highly tolerable. |
| priorityDate | 1970-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.