| abstract |
A procedure for the preparation of a 1,4-benzodiazepin-2-one having the formula: ** (See formula) ** where: R is selected from the group consisting of hydrogen and chlorine, and n is a positive integer from 1 to 3, inclusive; comprising the operations of: (1) reacting a compound having the formula: ** (See formula) ** where R and n are as defined above, with bromoacetyl bromide, to give a compound having the formula: ** (See formula) ** (2) react the compound of step 1 with ammonia in a lower alkanol solvent, to give the desired 1,4-benzodiazepin-2-one. (Machine-translation by Google Translate, not legally binding) |