http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-389204-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-85 |
| filingDate | 1971-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-389204-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING 1,2 - DIHYDRO - PIRIDO - (2,3-D) PYRIMIDIN 2 -ONAS. |
| abstract | Procedure for obtaining 1,2-dihydro-pyrido [2,3-d] pyrimidin-2-one, of formula Ia, where R means a hydrogen atom, an alkyl radical of 1 to 5 carbon atoms. R1 means an alkyl radical of 1 to 6 carbon atoms, a cycloalkyl radical of 5 to 6 ring members, or the allyl, metalyl or propargyl radical, and R2 means the phenyl radical or a substituted phenyl radical of formula II, **(See formula)** where Y means a fluorine, chlorine or bromine atom, or an alkyl or alkoxy radical of 1 to 4 carbon atoms, and Y1 means a hydrogen, fluorine, chlorine or bromine atom, or an alkyl or alkoxy radical of 1 to carbon atoms, characterized by that a compound of formula V is reacted, **(See formula)** where R, R1 and R2 have the meanings indicated above, with a carbonic acid derivative selected from the group consisting of (i) phosgene, preferably in an inert organic solvent and conveniently in the presence of an acid binding agent, and conveniently at a temperature between 10º and 30ºC, (ii) a C1-2 alkyl chlorocarbonate, preferably ethyl chlorocarbonate, conveniently in an inert organic solvent, and in the presence of an acid binding agent, and conveniently at a temperature of 60º to 100ºC, (iii) a C-alkyl carbamate, preferably urethanes, (iv) 1,1'-carbonyldiimidazole, conveniently in an inert organic solvent and at a temperature of 60º to 90ºC, with the proviso that when a compound of formula Ia is required, where R1 means a tertiary alkyl group, where the tertiary carbon atom is linked directly to the nitrogen atom of the ring, the reaction is carried out with phosgene or 1,1'-carbonyldiimidazole, and provided that when a C1-C5 alkyl carbonate is used, the reaction is carried out at a temperature of at least 140ºC, preferably at a temperature of 100º to 180ºC. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1968-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.