http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-386172-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56ee5285e8e8edccb061046ff20da7a6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J19-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0055 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07G- |
| filingDate | 1970-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-386172-A1 |
| titleOfInvention | IMPROVED PROCEDURE FOR THE PREPARATION OF PURE DIGOXIN MONOMETHYLETES. |
| abstract | The preparation of 3111- and 4111-O-methyldigoxin by reacting digoxin with dimethyl sulphate in dimethylformamide in the presence of barium hydroxide, is effected selectively by the additional presence of (a) aluminium oxide and an inert organic solvent or (b) aluminium isopropylate. The reaction mixture is then diluted with chloroform, and, after the addition of pyridine, evaporated in vacuo. The residue is separated, e.g. by multiplicative partition, into unreacted digoxin, which may be recycled, and (a) 4111-O-methyl-digoxin or (b) 3111-O-methyldigoxin respectively. |
| priorityDate | 1969-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.