http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-373371-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1969-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-373371-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF ORGANOSILANO-PENICYLINS. |
| abstract | A procedure for the preparation of organosilane-penicillins of the general formula **(See formula)** where R1 is hydrogen, alkyl, aryl, or aralkyl; R2 is halogen, alkyl, aryl, or aralkyl; Ra is an acyl radical of an organic carboxylic acid; W is hydrogen or a radical of the formula **(See formula)** where R1 and R2 have the meaning assigned to them before and X is halogen, m is 0 or 1; n is an integer valued from 1 to 25; p is 0 or 1; and Y is halogen or a group of the formula **(See formula)** in which Ra has the same meaning that has been attributed to it before, with the conditions that, in formula (I): (1) when m is 0 and p is 0, n is more than 1 and the two free valences are linked together to complete a cyclic compound; (2) when n is more than 1, the molecular fractions A of the additional groups B are randomly arranged from head to head, head to tail and tail to tail, (3) W is not hydrogen when n is 1 or Y has the formula (III); (4) m and p are always the same; and (5) when R1 and R2 are both chosen from alkyl, aryl and aralkyl, Ra contains an amine group on the alpha carbon atom together with the carboxylic group of the acyl radical), which can be optionally hydrolyzed to form penicillins or salts thereof, characterized by acylating a respective derivative of organosilane-6-aminipenicilanic acid, of the general formula (I) in which R1, R2, W, m, n, po Y have the meaning defined above and conditions (1), (2), (3) and (4) apply, but where Ra is a hydrogen atom, with a reactive derivative of an organic carboxylic acid Rb-CO -OH (where Rb-CO- is an acyl group, it being understood that Rb contains an amine group on the alpha carbon atom together with the carboxylic group when the acylan silane-6-amino-penicilllanic acid derivative has both symbols R1 and R2 taken from the alkyl, aryl and aralkyl groups), preferably in a non-hydroxylic organic solvent and preferably in the presence of an acid acceptor. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1969-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 14.