http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-372886-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_404c787d6b2e4d3f135ee391f79199a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1969-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-372886-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF 19 NOR-STEROIDS. |
| abstract | 19 - Nor - 3 - keto - #4 - steroids are prepared by reacting 19-hydroxy-3-keto-#4-steroids with secondary amines to give 19-nor-3-enamines (3,5-dienes) and hydrolysing these. Further standard conversions can be carried out on the enamine at other parts of the molecule before hydrolysis, or hydrolysis may accompany such conversions. Specified conversions are: reduction of an 11-, 16-, 17- or 20-oxo group to two hydrogen atoms or to a hydroxy group (ii) conversion of an 11-, 16-, 17- or 20-oxo group to an group where R is C 1-8 alkyl, C 2-4 alkenyl or C 2-4 alkynyl (iii) conversion of a 16[alpha],17[alpha]- epoxy - 16# - methyl - 17# - acetyl grouping to a 16-methylene-17[alpha]-(hydroxy or acyloxy)-17#- acetyl grouping (iv) introduction of a #- ethoxycarbonylethyl or #-cyanoethyl group in the 4-position and (v) introduction of an acetyl or propionyl group in the 4- or 6-position. 19 - Hydroxy - 4 - androstene - 3,16 - dione (XI) is prepared from 3#-acetoxy-5-androsten- 16-one (X) by the sequence X#3#-acetoxy- 5[alpha] - chloro - 6# - hydroxyandrostan - 16 - one #3# - acetoxy - 5[alpha] - chloro - 6#,19 - epoxyandrostan - 16 - one#5[alpha] - chloro - 6#,19-epoxyandrostane - 3,16 - dione#6#,19 - epoxy - 4 - androstene- 3,16-dione#XI. 16[alpha],17[alpha] - Epoxy - 16# - methyl - 19 - hydroxy- 4-pregnene-3,20-dione (XIV) is prepared from 3# - acetoxy - 16[alpha],17[alpha] - epoxy - 16# - methyl- 5-pregnen-20-one (XIII) by the sequence XIII#3# - acetoxy - 5[alpha] - bromo - 6# - hydroxy- 16[alpha],17[alpha] - epoxy - 16# - methylpregnan - 20 - one #3# - acetoxy - 5[alpha] - bromo - 6#,19 16[alpha],17[alpha]- diepoxy - 16# - methylpregnan - 20 - one#3#- acetoxy - 6#,19 16[alpha],17[alpha] - diepoxy - 16# - methyl- 4 - pregnen - 20 - one#3# - hydroxy - 6#,19 16[alpha],17[alpha] - diepoxy - 16# - methyl - 4 - pregnen- 20 - one#6#,19 16[alpha],17[alpha] - diepoxy - 16#- methyl - 4 - pregnene - 3,20 - dione#XIV |
| priorityDate | 1968-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.