http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-371555-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 |
| filingDate | 1969-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-371555-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF A PENICILLIN OR CEPHALOSPORIN. |
| abstract | A process for the preparation of a penicillin or cephalosporin or one of its 2-amido derivatives of the general formulas ** (see formula) ** or **(See formula)** where is a penicillin or cephalosporin amide group, X is an electron subtractor group, Y can be an electron subtractor group or not or X and Y are joined to form a cyclic electron subtractor group and R18 is a methyl, hydroxymethyl, N-pyridinylmethyl or alkanoyloxymethyl group; wherein a penicillin or cephalosporin, if desired, after first converting the 2-carboxy group to a functional derived group, is reacted with a reactive amine derivative to replace the original 2-carboxy group hydroxy fraction with an amido group. of the formula ** (see formula) **; if desired, the obtained 2-amidopenicillin or 2-amidocephalosporin is reacted in an aprotic solvent, inert to reaction with a phosphorous pentahalide in the presence of a base to provide a 2-amido-6-haloimidopenicillin or 2-amido- Corresponding 7-haloimidocephalosporin which is reacted with an alkanol to provide the halohydrate of a corresponding 2-amido-6-alkoxyimidopenicillin or 2-amido-7-alkoxyimidocephalosporin which in turn hydrolyzes with water to provide a 2-amido acid halohydrate -6-aminopenicillanic or 2-amido-7-aminocephalosporinic acid, which is neutralized, if desired, and 2-amido-6-aminopenicillanic acid or 2-amido-7-aminocephalosporinic acid or one of its addition salts Acid is reacted with an acylating agent to provide a subsequent 2-amidopenicillin or 2-amidocephalosporin which, if desired, hydrolyzes to form the corresponding penicillin or cephalosporin. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1968-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.