http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-368949-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G02B27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G02B27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 1969-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-368949-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING 3,4-DIHIDROQUINAZOLINO-NAS. |
| abstract | The invention comprises compounds of formula wherein n is 1 or 2, R when n = 1 is H, F, Cl, Br, C 1-5 alkyl, C 1-4 alkoxy, alkythio or alkylamino, di(C 1-4 alkyl)amino, NO 2, CN, NH 2, OH, SH, AcNH or CF 3, R when n = 2 is H, F, Cl, Br, C 1-5 alkyl or C 1-4 alkoxy, R 1 is C 1-5 alkyl, R 2 is H, C 1-5 alkyl or omega-di(C 1-4 alkyl)- amino-C 1-4 -alkyl, and R 3 is Ph possibly containing up to 2 substituents which are F, Cl, Br, C 1-4 alkyl or C 1-4 alkoxy and/or a CF 3 group. These compounds may be prepared by (1) hydrogenating the 3,4 - dehydro analogues (2) alkylating the 3-position (3) reacting the 3,4- dehydro analogues with an alkyl-lithium or Grignard compound (4) cyclizing a corresponding 1 - alkyl - 1 - (2 - benzoyl)phenylurea or a 1 -alkyl- 1 -phenylurea/benzaldehyde mixture (5) alkylating in the compound where R is amino or alkylamino, to give an alkylamino or dialkylamino group (6) reductively alkylating the compound where R is nitro. Starting materials.-Details are given for the preparation of 2-isopropylamino-4-methylbenzophenone, N-isopropyl-m-toluidene and its N- carbamyl derivative, p-chloro-N-methylaniline and its N-formyl derivative, 2-amino-5-chloro- 4-methylbenzhydrol and its N-isopropyl derivative, and 2-(N-ethyl or -isopropyl)amino-5- nitrobenzophenone. Therapeutic compositions having antiinflammatory, and in some cases antipyretic or analgesic activity, comprise compounds of the above formula in association with a physiologically acceptable diluent or carrier for oral or parenteral administration. |
| priorityDate | 1968-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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