http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-368607-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f88f84fc279fe5d0b9b5ec3c88c2e2b2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-33 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-333 |
| filingDate | 1969-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-368607-A1 |
| titleOfInvention | A PROCEDURE FOR THE PRODUCTION OF SELECTED COMPOUNDS FROM THE GROUP OF THE 1-SUBSTITUTED-2,5-DIPHENYLPIRROLS. |
| abstract | Novel 1 - substituted - 2,5 - diphenyl-pyrroles of the general formula wherein R is an amino, hydroxy, 1,2-dihydroxyethyl, 1,3-dioxolan-2-on-4-yl, aryloxy, optionally N-substituted carbamoyloxy, morpholinyl, N - acylpiperidinyl - 4 - carbonyloxy, 1 - acylpiperazinyl - 4 - carbonyloxy, pyrrolidinyl or piperidinyl group, R1 is a hydrogen, fluorine, chlorine or bromine atom or a C 1-8 alkyl, C 1-8 alkoxy or trifluoromethyl group, and n is an integer from 1 to 5 inclusive, and acid addition salts thereof are prepared (a) by reaction of a 2,5-diphenyl-pyrrole of the general formula with a compound of the general formula X(CH 2 ) n R, wherein X is a halogen atom (b) by reaction of a 1,2-dibenzoylethane of the general formula with an amine of the general formula NH 2 (CH 2 ) n R (c) when R is a 1,3-dioxolan-2- on-4-yl group, by reaction of the corresponding compound wherein R is a 1,2-dihydroxyethyl group with phosgene (d) when R is an N-alkylcarbamoyloxy group, by reaction of the corresponding compound wherein R is a hydroxy group with an alkyl isocyanate (e) when R is a 1-acyl-4-piperidinylcarbonyloxy group, by reaction of the corresponding compound, wherein R is a hydroxy group with 1-acyl-isonipecotic acid halide and (f) when R is a 1-acyl-4- piperazinylcarbonyloxy group, by reaction of the corresponding compound wherein R is a hydroxy group with 4-halocarbonyl-1-acylpiperazine followed optionally by salification of the product. Pharmaceutical compositions having analgesic activity comprise, as active ingredient, a 1- substituted-2,5-diphenyl-pyrrole of the first general formula above or a non-toxic acid addition salt thereof, together with a pharmaceutically acceptable carrier, and may be administered orally or parenterally. |
| priorityDate | 1968-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.