http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-368555-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f88f84fc279fe5d0b9b5ec3c88c2e2b2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-08 |
| filingDate | 1969-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-368555-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF I - CARBAMOIL - 3 - AROYLPYRROLIDINES. |
| abstract | Novel compounds of the formula where R1 and R2 each denote H, C 1-8 alkyl, C 3-9 cycloalkyl or aryl, and R3 denotes H, F, Cl, Br, CF 3 or C 1-8 alkyl, and acid addition salts thereof, may be obtained by the steps: (1) reacting a 1 - benzyl - 3 - cyano - pyrrolidine with Aryl- Mg-X (where X = Cl or Br) to yielda 1-benzyl-3- aroylpyrrolidine, (2) reacting the product with CNBr to form a 1-cyano-3-aroylpyrrolidine, (3) refluxing the latter with 4N HCl to yield a 1- carbamoyl-3-aroylpyrrolidine, and optionally (4) hydrolysing the product of (3) by prolonged refluxing with conc. HCl to form a 3-aroylpyrrolidine, and (5) reacting the product with a C 1-8 alkyl isocyanate, aryl isocyanate, N-C 3-9 cycloalkyl-N-aryl carbamoyl halides, N,N-di- C 1-8 alkyl carbamoyl halide or N,N-diaryl carbamoyl halide. The compounds have anticonvulsant activity. N-R1,N-R2-Carbamoyl chlorides are obtained by reacting the corresponding amine R1R2NH with phosgene. |
| priorityDate | 1968-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.