http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-367809-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 |
| filingDate | 1969-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-367809-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF 9BETA, 10ALFA, -ESTE- ROIDES. |
| abstract | The invention comprises compounds of formula wherein R is a 3 - oxo - #4, 3 - oxo - #1'4, 3 - oxo- #4'6, 3 - oxo - #1'4'6, 3 - "alkoxy" - #3'5, 3- "alkoxy" - #4'6, 3 - acyloxy - #3'5, 3 - acyloxy- #4'6, 3 - acyloxy - #2'4'6 or 3 - hydroxy - #4'6 system, and R1 is H or acyl. The term "alkoxy" is defined as a C 1-10 aliphatic, cycloaliphatic, aromatic or araliphatic etherified hydroxy group. Compounds I (R=3 - hydroxy - #4'6 R1 = H) are prepared by reduction of the corresponding 3,20-diones. Compounds I (R=3À oxo - #4 or 3 - oxo - #4'6 R1 = acyl) are prepared by chlorination of the corresponding 6 - dechloro - 3 - acyloxy - #3'5, 6 - dechloro - 3- alkoxy - #3'5 or 6 - dechloro - 3 - oxo - #4'6 compounds. Compounds I are interconvertible by oxidation of a 3,20-diol to a 20-ol-3-one, 1,2- and/or 6,7-dehydrogenation, saponification of 20-acylates, esterification, etherification, enol-esterification and enol-etherification. 9#,10[alpha] - Pregna - 3,5 - diene - 3,20[alpha] - diol diacetate is prepared from 20[alpha] - hydroxy - 9#, 10[alpha]- pregn - 4 - en - 3 - one by reaction with isopropenyl acetate. Compounds I are stated to possess progestational and antiestrogenic activity and to influence gonadotropin secretion or production, and may be made up with carriers into pharmaceutical compositions for oral and parenteral administration. |
| priorityDate | 1968-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 17.