http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-366651-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate | 1969-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-366651-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW ESTRADIOL-17 BETA-RAMNOSIDES. |
| abstract | The invention comprises compounds of formula wherein R 1 is a group of structure A or B where each R 3 is H or -COR 4 R 4 is C 1-3 alkyl and R 2 is H, C 1-3 alkyl, acyl, benzyl, tetrahydropyran-2-yl or -SO 3 M, where M is an alkali metal atom. Compounds I wherein R 2 is other than -SO 3 M and R 3 is -COR 4 are prepared by reacting the corresponding 17-ols with a trio - alkanoyl - [alpha] - L - rhamnopyranosyl halide to give a product comprising structure A and/or structure B. When a mixture is obtained it is separated by saponification of the alkanoyl groups and chromatography of the resulting deacyl mixture. Compounds I wherein R 2 is -SO 3 M and R 3 is H are prepared from compounds I wherein R 2 is H and R 3 is -COR 4 by reaction with sulphamic acid and treatment of the resulting 3-hemisulphate with an alkali. Other product interconversions described are esterification, saponification of ester groups, 3- etherification, and 3-debenzylation. |
| priorityDate | 1968-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 14.