http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-366536-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b6fc801b5bfe5304ffa40d938db6e09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-327 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-327 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate | 1969-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-366536-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW ESTERS OF ACI-DOS SUBSTITUTED PHENYLACETICS. |
| abstract | The invention comprises compounds of formula wherein R 1 is H, Me or Et, R 2 is H, F, Cl or Br, A is C 2-3 alkylene (with at least 2C atoms between the O and N atoms), and R 3 , R 4 are each C 1-4 alkyl, or NR 3 R 4 is pyrrolidino, piperidino, hexamethyleneimino or morpholino and pharmaceutically acceptable acid addition salts thereof. These compounds are prepared by (a) forming the ester group by standard methods or (b) forming the pyrrole ring by reacting the corresponding precursor having NH 2 instead of 1-pyrryl in the above formula with e.g. succinaldehyde or 2,5-dimethoxytetrahydrofuran. Details are given of the preparation of the following intermediates: 2 - (p - 1 - pyrrylphenyl)alkanoic acids, esters (and 2-carboalkoxy derivatives of the esters) and an acid chloride 2- (p - aminophenyl)alkanoic acids, aminoalkyl and alkyl esters (and their 2-carboalkoxy derivatives) m-chloro derivatives of the foregoing 2-(4- acetamino - 3 - chlorophenyl)alkanoic acids and diethyl 2 - (3 - chloro - 4 - nitrophenyl) - 2- methylmalonate. Therapeutic compositions for oral, rectal, parenteral or local administration comprise compounds of the above formula with a diluent or carrier, and have analgetic, antiphlogistic and musculotropic-spasmolytic activity. |
| priorityDate | 1968-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.