http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-366527-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 |
| filingDate | 1969-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-366527-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING 4 - (P- (OMEGA - AMINOAL-COXI) -PHENYL) PYRIMIDINES. |
| abstract | Compounds of the general formula (wherein the R 1 's are the same or different and are each C 1-4 alkyl other than tert.-butyl, or together represent (CH 2 ) 4 or 5 the R 2 's are the same or different and are each H or C 1-4 alkyl other than tert.-butyl Y is a radical of the formula (Z 1 =NH 2 or Ph, or Z 2 =2-thienyl or Ph)) and their acid addition salts are prepared by (i) reacting a compound of the formula with guanidine or benzamidine or a salt thereof under basic conditions in the presence of an inert organic solvent at elevated temperature, (ii) reacting a compound of the formula with Z 2 COCH 2 A#X# (A=Py or quinolyl X=Cl, Br, I) and ammonium acetate in the presence of a solvent at elevated temperature, (iii) reacting a compound of the formula (M=alkali metal) with a compound of the formula (Hal = Cl, Br, I the R1 2 's-are the same or different and are each H or C 1-4 alkyl other than tert.-butyl the R x 's are both H or both C 1-4 alkyl other than tert.-butyl provided that when the R x 's are alkyl both the R1 2 's are H) in an inert solvent, or (iv) reducing a compound of the formula in an inert solvent, using a reducing agent known to reduce the CO group of an amide to CH 2 , optionally followed in each case by salt formation. The preparation of the chalcone starting materials for processes (i) and (ii), amide starting materials for process (iv) and p-(2-diethylaminoethoxylbenzaldehyde, 1-(2-thenoylmethyl)pyridinium bromide, 4-(1,1-dimethyl-2-dimethylaminoethoxy)benzaldehyde and 2-methyl-2-[4-(21,61-diphenylpyrid-41-yl)phenoxy]propionic acid and its ethyl ester is described. The compounds of the invention possess hypocholesteraemic and/or hypotriglyceraemic activity, and some of them possess anticonvulsant activity. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier. |
| priorityDate | 1968-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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