http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-363959-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_404c787d6b2e4d3f135ee391f79199a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N45-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N45-02 |
| filingDate | 1969-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1971-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-363959-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING A DERIVATIVE OF HALOGENOCOLQUICINE. |
| abstract | Novel compounds (I): wherein R1 is a mono-, di- or tri-haloacyl radical containing 2 to 10 carbons and R2 is MeO, MeS, MeSO, MeSO 2 or NR3R4 (R3 is alkyl and R4 is H or alkyl), are obtained: (a) by acylating corresponding compounds in which R1 is H (b) by introducing a 2-methyl radical and/or an R2- substituent into a corresponding compound not containing said radical and/or substituent, and/ or into the corresponding isocolchicine compound, e.g. methylation of corresponding 2- and/or 4-hydroxy compounds (c) by reacting methyl mercaptan with a corresponding compound wherein R2 is MeO or OH, or with the corresponding isocolchicine compound, and, if desired, oxidizing the thioether (I) so obtained (d) by reacting an amine, NHR3R4, with a corresponding compound in which R2 is MeO or OH, or with the corresponding isocolchicine compound and (e) by replacing halogen in the substituent R1 by another halogen. Desacetyl - N - chloroacetyl - colchiceine is prepared by the interaction of desacetylcolchiceine and chloracetyl chloride the N- bromoacetyl compound is prepared utilizing bromoacetyl chloride. Desacetyl 14 - desmethoxy -14 - dimethylaminocolchicine is prepared by the interaction of desacetyl-colchicine and dimethylamine. Pharmaceutical preparations showing antimitotic, cytostatic and/or gout healing action contain as active ingredient compounds (I) administration is parenterally, enterally or topically. |
| priorityDate | 1968-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.