http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-362742-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dade192ee874089d5a71388395b6069f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- |
| filingDate | 1969-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-362742-A1 |
| titleOfInvention | WATER-SOLUBLE SULFONAMIDES PREPARATION PROCEDURE. |
| abstract | Procedure for the preparation of water-soluble sulfonamides, in the entire pH range, of the general formula: **(See formula)** in which R is a substituent of the known sulfonamides, that is, an aminophenyl radical, p-, o-, m-nitrophenyl, acylaminophenyl, phenyl, phenylalkyl, phenylalkylamino, sulfoalkoylaminophenyl, carboxyalkoylaminophenyl, nitroamine, phenyl-phenyl, p-hydrazinophanyl, -p p-nitrofurfurylidene-hydrazino-phenyl, etc .; R1 is a usual substituent for known sulfonamides, i.e. hydrogen, (if R1 is hydrogen, the carbon number of R2 must be greater than 2), an alkoyl or aryl radical, a nitrogenous, sulfurized or carbon heterocyclic radical, substituted alkoxyloxy, substituted halogen, substituted alkoxyhalogen, etc., thioalkoxy, thioalkoyl; R1 can also be identical to R2 or as defined for R2; R2 is of the A-SO3B or A-CO2B type, formulas in which B designates a base, for example choline, methylcholine, etc. or an alkali or alkaline earth metal such as sodium, potassium, etc., and A is a straight-chain, branched or cyclic hydrocarbon radical, substituted or unsubstituted, as well as metal salts, amine salts and organic bases, characterized by that a basic derivative of a sulfonamide that eventually carries an R and/or R1 substituent or precursors is condensed with a sultone or a lactone, which gives a basic sultonate or a basic lactonate that carries the sulfonamide or its precursor in N1, being the precursor used as is or being transformed into the desired sulfonamide, because a basic derivative of a sulfonamide is condensed, optionally bearing an R and/or R1 substituent or precursors with a halogen-A'-basic sulfonate or a halogen -A' -carboxylate basic, A'designating a hydrocarbon radical, such as an aryl, alkoyl or arylalkyl radical, or because a sulfonyl halide of formula R-S02-Hal is reacted in which R has the same meaning as above ormente, with an amine of formula (see formula) in which Y represents hydrogen or a metal and R1 and R2 have the same meaning as above, this amine can be obtained either by the action of a compound of formula Hal-R1 with an amine of formula NH2-R2 that It can be an amino acid such as glycol, alanine, taurine, aminomethylsulfonic acid, aminopropanesulfonic acid, etc., or by the action of an amine of formula NH2-R1 with a sultone, a lactone or a precursor. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1968-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.