http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-362305-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b6fc801b5bfe5304ffa40d938db6e09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-60 |
| filingDate | 1968-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-362305-A1 |
| titleOfInvention | PROCEDURE FOR THE PRODUCTION OF 4-PHENYLIMINE - 1,4 - DIHYDROQUINOLINES. |
| abstract | Novel compounds of Formula I and tautomers thereof (when R 5 is H) of Formula V and acid addition salts thereof, wherein R 1 is H, C 1-5 alkyl, C 3 _ 5 cycloalkyl, or non-geminal dihydroxy (C 1-5 )alkyl, R 2 ,R 3 and R 4 are each H, halogen, C 1-5 alkyl, C 1-5 alkoxy or CF 3 , R 5 is H, OH, C 1 _ 5 alkyl or aryl (C 1-5 )alkyl, R 6 is H, C 1-5 alkyl, aryl or aryl(C 1-5 )alkyl, R 7 is H or C 1-5 alkyl, "aryl" means phenyl optionally substituted by C 1-5 alkyl, C 1-5 alkoxy OH, CF 3 or halogen and n is 0 or 1, are prepared by condensation of a compound of formula wherein X is halogen or phenoxy, Y is halogen, sulphate or p-toluene sulphonate, R 2 , R 3 , R 4 and R 6 are as above and R5 is as defined above or is hydroxy, with a compound of Formula III wherein R1 1 represents in addition to the above meanings of R 1 a protected-hydroxy or-non- geminal dihydroxy-C 1 _ 5 alkyl group, the said protected hydroxy groups being tetrahydropyranyloxy, non-geminal alkylenedioxy or alkidenedioxy, and R 2 , R 7 and n are as above, followed by hydrolysis of protected hydroxy groups and optionally followed by reaction with R1 5 Y if R 5 is H in product, R1 5 being R 5 other than H, and/or hydrolysis to convert R 1 to H and/or salt formation. Intermediates of Formula III above are prepared by reduction of the corresponding nitro-compounds which are prepared by esterification of the corresponding acids. Pharmaceutical compositions having antiinflammatory, anti-malarial, anti-pyretic and analgesic activity and being in conventional forms for oral, rectal or parenteral administration comprise an above novel compound or salt thereof and a carrier therefor. |
| priorityDate | 1967-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.