http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-357030-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-24 |
| filingDate | 1968-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-357030-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF BENZODIA-CEPINE DERIVATIVES. |
| abstract | Procedure for the preparation of benzodiazepine derivatives of the general formula **(See formula)** wherein R1 is hydrogen, halogen, trifluoromethyl, nitro, or amino, R2 is alkyl, alkenyl, cycloalkyl, cycloalkenyl, pyridyl, phenyl, or phenyl substituted by halogen; R3 is alkoxy, benzyloxy, phenyloxy, amino, dialkylamino or alkylthio, and R4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, monoalkylamino-alkyl or dialkylamino-alkyl, and the acid addition salts of the compounds which The alkaline, alkaline earth, ammonium, alkylammonic, dialkylammonic and trialkylammonic salts of 3-carboxylic acid, the respective deoxygenated compounds, which may carry a hydroxylic, alkanoxyloxy, aroyloxylic or aralkanoyloxylic group in position 3, and the respective decarboxylated compounds are basic in character., a procedure characterized by; 1) cyclizing a compound of the formula **(See formula)** where R1, R2, R3 and R4 have the same meaning as explained above, while R5 is a part group, in the presence of basic or acidic agents, and if desired, subject the obtained compound to one or more reaction steps chosen from; a) renting, alkenylating or alkylating a compound that is unsubstituted in position 1; b) nitrating a compound that is unsubstituted at position 7; c) converting the amine groups into halogen groups; d) saponifying a 3-carboxylic acid ester or amide to form a 3-carboxylic acid salt; e) decarboxylate a 3-carhoxylic acid salt or the respective acid released therefrom, f) deoxygenate a obtained nitrone, to form the respective 4-deoxylic compound; g) converting a nitrone of the formula I to a compound of the formula **(See formula)** where R, R2, R3 and R4 have the same meaning as explained above, while R7 is alkancil, clay or aralkyl; h) hydrolyzing a compound obtained, of the general formula III, to form a compound of the general formula **(See formula)** where R1, R2, R3 and R4 have the same meaning as previously stated; and i) transforming a basic compound into an acid addition salt; O well 2) oxidizing a respective 4-deoxylic compound. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1967-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.