http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-354273-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30432c021c19453629a3b69ce104640e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-95 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95 |
| filingDate | 1968-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-354273-A1 |
| titleOfInvention | PROCEDURE FOR THE PRODUCTION OF 2,4-DIA-MINO-6- (NITROSAMINE SUBSTITUTED) QUINAZOLINE COMPOUNDS |
| abstract | Novel 2,4-diamino-6-(substituted nitrosamino)-quinazoline derivatives of the general formula wherein R is hydrogen or a C 1-4 alkyl group X is hydrogen, chlorine or a methyl group and Ar is a phenyl, naphthyl, furyl, thienyl or pyridyl radical or a phenyl radical substituted by one, two or three substituents selected from C 1-4 alkyl and C 1-4 alkoxy groups and halogens and acid addition salts thereof are prepared by reaction of a 2,4-diamino-6-(substituted amino)-quinazoline derivative of the formula or an acid addition salt thereof with a nitrosating agent, followed optionally by conversion to an acid addition salt of the product. 2,4 - Diamino - 6 - (substituted amino) - quinazoline derivatives of the second formula above are prepared by reaction of an aldehyde of the formula Ar-CHO or a ketal of the formula wherein "lower alkyl" is C 1-4 alkyl, with a 2,4,6 - triaminoquinazoline of the formula followed by reduction of the resulting aralkylidene compound of the formula 2,4,6 - Triaminoquinazolines of the fourth formula above are prepared by reduction of the corresponding 2,4 - diamino - 6 - nitroquinazolines, which may be obtained by nitration of the corresponding 2,4 - diaminoquinazolines. 2,4 - Diamino - 5 - methyl - 6 - nitroquinazoline acetate is prepared by treating 2 - methyl - 6 - chlorobenzonitrile with nitric acid, reacting the resulting 2 - methyl - 3 - nitro - 6 - chlorobenzonitrile with guanidine carbonate and treating the resulting free base with acetic acid. 2,4 - Diamino - 5 - chloroquinazoline hydrochloride is prepared by reaction of 2 - amino - 6 - chlorobenzonitrile with cyanamide dihydrochloride. |
| priorityDate | 1967-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.