http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-352201-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7f1a4cbdd4777314999fe906c1ca45d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 |
| filingDate | 1968-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-352201-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF TEBAINA YORIPAVINA. |
| abstract | Novel thebaine and oripavine derivatives of the general formula wherein Y represents the ethero (-CH = CH-) or the ethano (-CH 2 -CH 2 -) group, Q represents one of the radicals R represents a methyl group or a hydrogen atom, R1 represents a hydrogen atom, an alkyl or alkenyl group of up to 3 carbon atoms, a phenyl or a tolyl group, R2 represents a cycloalkyl group of 5 to 7 carbon atoms, an alkyl or alkenyl group of up to 8 carbon atoms, a benzyl or a phenethyl group, R3 represents an alkyl group of up to 5 carbon atoms, a cycloalkylmethyl of 4 to 6 carbon atoms, an allyl, methylallyl, dimethylallyl or crotyl group R4 represents an alkyl group of up to 5 carbon atoms, and their acid addition salts are prepared by dehydrogenating compounds of general formula wherein R, R3, Q and Y are as defined above. The above compounds where Q is the group may also be prepared by treating a compound of general formula (A) wherein Y, R, R1, R2 and R3 are as defined above and Q is the group with respectively a Grignard reagent R2MgX or an alkyl lithium, LiR2 or with a Grignard reagent R1MgX or an alkyl lithium LiR1, where X is a halogen atom. The above compounds where Q is the group may also be prepared by treating a compound of general Formula (A), wherein Y, R, R1, R2 and R3 are as defined above and Q is the group with lithium aluminium hydride or aluminium isopropoxide. The above compounds where Q is the group (where R1=R 2 ) may also be prepared by treating a compound of general Formula (A) wherein Y, R, R4, R1 and R3 are as defined above and Q is the group with two moles of a Grignard reagent R1MgX or an alkyl lithium LiR1, wherein X is a halogen atom. Pharmaceutical compositions containing the above compounds where Q = having analgesic and antitussive activity may be administered orally or parenterally. |
| priorityDate | 1967-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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