http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-345065-A1
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| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5922cbe7c65a9136f85906fa09e7c967 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- |
| filingDate | 1967-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1969-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-345065-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF LONG CHAIN HYDROCAR-BONDED DERIVATIVES. |
| abstract | A process for the preparation of long chain hydrocarbon derivatives consisting of treating a compound of the formula: **(See formula)** where each of the radicals R1, R2, R3 and R4 is alkyl of 1 to 6 carbon atoms, Z6'and Z7' is hydrogen c, taken together, a carbon-carbon double bond; and Z10'and Z11' are hydrogen or, taken together, a carbon-carbon double bond; in optional order and to the degree required and desired with A) a carboalkoxymethylphosphonate to give the corresponding alkyl 2,6,10-trienoate hydrocarbon ester or the 6,7- and/or 10,11-dihydrogenated derivatives thereof; and 1) hydrolyzing the hydrocarbon alkyl eneate ester to the corresponding 2,6,10-trienoic hydrocarbon acid or the 6,7- and/or 10,11-dihydrogenated derivatives thereof; me 2) reducing the hydrocarbon alkyl eneate ester to give the corresponding 2,6,10-trien-1-ol hydrocarbon or the 6,7- and/or 10,11-dihydrogenated derivatives thereof; me 3) treating the hydrocarbon alkyl eneate ester with an alkali metal amine salt to give the corresponding hydrocarbon 2,6,10-trienamide or the 6,7- and/or 10,11-dihydrogenated derivatives thereof; or with B) vinylmagnesium bromide to give the corresponding 1,6,10-trien-3-ol hydrocarbon or the 6,7-and/or 10,11-dihydrogen derivatives thereof and treat the enol thus prepared with a phosphorous trihalide to give the corresponding 2,6,10-trien-1-hydrocarbon halide or 6,7- and/or 10,11-dihydrogen derivatives thereof, and 1) treating the hydrocarbon en-1-halide with an amine to give the corresponding hydrocarbon 2,6,10-trienamine or the 6,7- and/or 10,11-dihydrogenated derivatives thereof; me 2) treating the hydrocarbon en-1-halide with a trisubstituted phosphite to give the corresponding hydrocarbon 2,6,10-trien-1-phosphonate or the 6,7-and/or 10,11-dihydrogenated derivatives thereof; and then treat, in optional order and to the required and desired degree, any of the compounds thus prepared by 1) introduction at positions C-2,3, C-6,7 and/or C-10,11 of the oxide group; 2) introduction of the methylene group at positions C-2,3, C-6,7 and/or C-10,11; 3) introduction of the difluoromethylene group at positions C-2,3, C-6,7 and/or C-10,11; 4) introduction of the dichloromethylene group at positions C-2,3, C-6,7 and/or C-10,11; 5) hydroxylation at positions C-2, C-3, C-6, C-7, C-10 and/or C-11; 6) etherification of any hydroxyl group; 7) esterification of any hydroxyl group; 8) halogenation at positions C-3, C-6, C-7, C-10 and/or C-11; 9) hydrogenation at positions C-2,3, C-6,7 and/or C-10,11; me 10) formation of the acid addition salts of the acids and amines; whereby a compound of the following formula is prepared: **(See formula)** where R is one of the groups (see formula), -CH2OR6, (see formula), -CH2X, -CH2NR7R8 and -CH2P (Or9) 2 in which R5 is hydrogen or alkyl; R6 is hydrogen, alkyl or acyl; R7 and R8 are each hydrogen, alkyl, hydroxyalkyl, alkyloxyalkyl, phenyl or taken together with the nitrogen atom to which they are attached, pyrrolidino, morpholino, piperidino, piperazino or 4-alkylpiperazino; R9 is alkyl or phenyl; and X is bromine, chlorine, or fluorine; R1, R2, R3 and R4 are each alkyl of 1 to 6 carbon atoms; Z2 is hydrogen or hydroxyl; Z2 is hydrogen, hydroxyl, alkoxy, bromine, chlorine, fluorine or, together with Z2, a carbon-carbon double bond between C-2,3 or one of the groups (see formula); Z6 is hydrogen, hydroxyl, bromine, chlorine, or fluorine; Z7 is hydrogen, hydroxyl, alkoxy, bromine, chlorine, fluorine or together with Z8, a carbon-carbon double bond between C-6,7 or one of the groups (see formula); Z10 is hydrogen, hydroxyl, bromine, chlorine, or fluorine; Z11 is hydrogen, hydroxyl, alkoxy, bromine, chlorine, fluorine or, together with Z, a carbon-carbon double bond between -C-10,11 or one of the groups (see formula); and the acid addition salts of acids and amines, bearing in mind that 1) when Z3 is hydrogen - then Z2 is hydrogen 2) when Z7 is hydrogen - then Z 6 is hydrogen 3) when Z11 is hydrogen - then Z10 is hydrogen 4) when R is the group (see formula) - then Z3 taken together with Z2, is a carbon-carbon double bond between C-2,3 or one of the groups (see formula); and 5) when R is the group (see formula) - then Z3 taken together with Z2 is a carbon-carbon double bond between C-2,3 or one of the groups (see formula). (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1966-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 35.